VW Applied Sciences, Volume: 4, Issue: 2, 146-153
Received: May 21, 2022
Accepted: July 06, 2022
Published online: July 09, 2022
Raafiah Izhar 1*, Gufran Ali 2
1Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
2Department of Pharmacology, J.N. Medical College & Hospital, A.M.U., Aligarh, U.P., India
Abstract: The gene targeting methods like CRISPR/Cas9, is one of the most powerful technologies for correcting inconsistent genetic signatures and are widely used against various types of diseases these days. CRISPR/Cas9-based strategies have the potential to treat complex diseases as it is a relatively straightforward, inexpensive, and precise system. This review article summarizes the applications of CRISPR/Cas9 genetic engineering in neurodegenerative disease models, providing therapeutic gene editing perspectives for neurological diseases. Here, understanding of CRISPR/Cas9 mediated genome editing in neurological diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease has been focused on targeting specific genes involved and its potential as the most promising and emerging technologies taking into account the low off-target effects of CRISPR/Cas9 and its highest editing efficiency.
Keywords: CRISPR/Cas9, Neurodegenerative disorder, Gene therapy
