CRISPR/Cas9

The gene targeting methods like CRISPR/Cas9, is one of the most powerful technologies for correcting inconsistent genetic signatures and is widely used against various types of diseases these days. CRISPR/Cas9 based strategies have the potential to treat complex diseases as it is relatively straightforward, inexpensive, and precise system. This review article summarizes the applications of CRISPR/Cas9 genetic engineering in neurodegenerative disease models, providing therapeutic gene editing perspectives for neurological diseases. Here, understanding of CRISPR/Cas9 mediated genome editing in neurological diseases such as Alzheimer, Parkinson and Huntington’s disease have been focused by targeting specific genes involved and its potential as the most promising and emerging technologies taking into account with the low off-target effects of CRISPR/Cas9 and its highest editing efficiency.